1National Genomics Data Center & Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China 2University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 101408, China 3Shanghai Southgene Technology Co., Ltd, Shanghai 201210, China 4Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China †These authors contributed equally to this work. *Correspondence to:Zefeng Wang , Email:wangzefeng@picb.ac.cn Guoqing Zhang , Email:gqzhang@picb.ac.cn